Figure 1

Comparison of the gene expression profiles of embryonic stem cells (ESCs) derived from different origins. Two sets (A and B) of comparisons were made using two lines of parthenogenetic ESCs (pESC-1 and pESC-2 for A and B, respectively). In each set, the gene expression profile of normally fertilized ESCs (nfESCs) derived from R1 strain was first compared with the profile of nfESCs derived from B6D2F1 strain. Comparisons were subsequently made between pESCs and nfESCs of the same strain (B6D2F1) and between pESCs and nfESCs of a different strain (R1). In the first comparison (A), the change in gene expression after parthenogenesis was less than the change attributable to the strain difference; the number of genes with altered expression was similar among all comparisons in the second set (B). (Reprinted with permission from Gong et al., Hum Reprod 2009; 24: 815-814).